SEQUENCE LISTING




       <110> The Governing Council of the
             University of Toronto

       <120> PROTEINS RELATED TO SCHIZOPHRENIA AND USES THEREOF
         

       <130> 9267-72/PAR


       <150> US 60/229,889

       <151> 2000-09-01


       <160> 19

       <170> FastSEQ for Windows Version 3.0

       <210> 1

       <400> 1
 000

       <210> 2

       <400> 2
 000

       <210> 3
       <211> 422
       <212> DNA
       <213> mouse

       <400> 3
 cccagcggag aggcaagatg gctacgacta ggggcggctc tgggcctgac ccaggaagtc      60
 ggggtcttct tcttctgtct ttttccgtgg tactggcagg attgtgtggg ggaaactcag     120
 tggagaggaa aatctacatt cccttaaata aaacagctcc ttgtgtccgc ctgctcaacg     180
 ccactcatca gattggctgc cagtcttcaa ttagtgggga tacaggggtt atccatgtag     240
 tggagaaaga agaagactga agtgggtgtt gacgatggcc ccaaccccct tacatggtct     300
 gctggaggga agtcttcaca gagatgtaat ggagaagctg aggacaacag tagatcctgg     360
 tcttgccgtg attagcagcc actcacttaa gtttctctag tgtgagtgcc aatgatgggt     420
 tt                                                                    422

       <210> 4
       <211> 473
       <212> DNA
       <213> unknown

       <220> 
       <223> EST from unknown organism

       <400> 4
 tggagaggaa aatctacatt cccttaaata aaacagctcc ttgtgtccgc ctgctcaacg      60
 ccactcatca gattggctgc cagtcttcaa ttagtgggga tacaggggtt atccatgtag     120
 tggagaaaga agaagacctg aagtgggtgt tgaccgatgg ccccaacccc ccttacatgg     180
 ttctgctgga gggcaagctc ttcaccagag atgtaatgga gaagctgaag ggaacaacca     240
 gtagaatcgc tggtcttgcc gtgactctag ccaagcccaa ctcaacttca agcttctctc     300
 ctagtgtgca gtgcccaaat gatgggtttg gtaattactc caactcctac gggccagagt     360
 ttgctcactg gaagaaaaca ctgtggaatg aactcggcaa aggcttggct tatgaagacc     420
 ttagtttccc caatcttcct cctggagatg aggaccgaaa caaggtcatc aag            473

       <210> 5

       <220> 
       <223> null

       <400> 5
 000

       <210> 6
       <211> 463
       <212> DNA
       <213> unknown

       <220> 
       <223> EST from unknown organism

       <400> 6
 gggctcgaaa catctctggc gtggtcctgg ctgaccactc tggctccttc cacaatcggt      60
 attaccagag catttatgac acggctgaga acattaatgt gacctatcct gagtggcaga     120
 gccatgaaga ggacctcaac tttgtgacag acactgccaa ggcactggcg aatgtggcca     180
 cagtgctggc gcgtgcactg tatgagcttg caggaggaac caacttcagc agctccatcc     240
 aggctgatcc ccagacagtt acacgtctgc tctatgggtt cctggttaga gctaacaact     300
 catggtttca gtcgatcctg aaacatgacc taaggtccta tttggatgac aggcctcttc     360
 aacactacat cgccgtctcc agccctacca acacgactta cgttgtgcag tacgccttgg     420
 caaacctgac tgggcaaggc gaccaacctc acccgagagc agt                       463

       <210> 7
       <211> 481
       <212> DNA
       <213> unknown

       <220> 
       <223> EST from unknown organism

       <400> 7
 gaggacctca actttgtgac agacactgcc aaggcactgg cgaatgtggc cacagtgctg      60
 gcgcgtgcac tgtatgagct tgcaggagga accaacttca gcagctccat ccaggctgat     120
 ccccagacag ttacacgtct gctctatggg ttcctggtta gagctaacaa ctcatggttt     180
 cagtcgatct tgaaacatga cctaaggtcc tatttggatg acaggcctct tcaacactac     240
 atcgccgtct ccagccctac caacacgact tacgttgtgc agtacgcctt ggcaaacctg     300
 actggcaagg cgaccaacct cacccgagag cagtgccagg atccaagtaa agtcccaaat     360
 gagagcaagg atttatatga atactcgtgg gtacaaggcc cttggaattc caacaggaca     420
 gagaggctcc cacagtgtgt gcgctcacag tgcgactggc aagggcttgt ccctgccttt     480
 g                                                                     481

       <210> 8
       <211> 398
       <212> DNA
       <213> unknown

       <220> 
       <223> EST from unknown organism

       <400> 8
 agagctaaca actcatggtt tcagtcgatc ttgaaacatg acctaaggcc tatttggatg      60
 acaggcctct tcaacactac atcgccgtct ccagccctac caacacgact tacgttgtgc     120
 agtacgcctt ggaaacctga ctggcaaggc gaccaacctc acccgagagc agtgccagga     180
 tccaagtaaa gtcccaaatg agagcaagga tttatatgaa tactcgtggg tacaaggccc     240
 ttggaattcc aacaggacag agaggctccc acagtgtgtg cgctccacag tgcgactggc     300
 cagggccttg tcccctgcct ttgaactgag tcagtggagc tccacagaat actctacgtg     360
 ggcggagagc cgctggaaag acatccaagc tcggatat                             398

       <210> 9
       <211> 172
       <212> DNA
       <213> unknown

       <220> 
       <223> EST from unknown organism

       <400> 9
 tgtgcgctcc acagtgcgac tggccagggc gttgtcacct gcctttgaac tgagtcagtg      60
 gagctccaca gaatactcta cgtgggcgga gagcgcgtgg aaagacatcc cagctcggat     120
 attcctaatt gccagcaaag agcttgagtt catcacgctg atcgtgggct tc             172

       <210> 10
       <211> 425
       <212> DNA
       <213> unknown

       <220> 
       <223> EST from unknown organism

       <400> 10
 tttttttttt ttttttgtat tgcataattt taatgaaact tgctatttat atacttacaa      60
 aaaaaaaaaa aaaggaaaaa accccaacaa aaatagataa ttatagttta ataataaaaa     120
 gtacaactga gcactgtggg ctggaggtgg gatacccact taacagcgtg cccacactaa     180
 catgccatct gcacacctgg agaaaggaca gtgggaaaga gacactggct cagccaggga     240
 atccatttct tccctaaggg ttcagggtag ttgaatgcag atgcacaatc tttcacaccc     300
 tcttcctggt gcagcaggtg gctgaatatg ggggaggggt gtcgggtgac agtggagtca     360
 gagggcagta cagggcagga tggaaggaca gaaggtatcc cgagaaaggg cagaggaggg     420
 tgggt                                                                 425

       <210> 11
       <211> 4560
       <212> DNA
       <213> C. Elegans

       <400> 11
 attaagaacg aatgagtcga tagaagcact gaaaaatgaa gaaatggcta gttatagtat      60
 taattatcgc tggaatacga tgcgacggat tttcggatca agttttccga actctgttca     120
 ttggagaagg aaatgcgtgc tatagaactt ttaataaaac gcacgaattc ggttgtcaag     180
 gtaaaaattg aatgatttca aataattaca tataaaaaaa tattgcactg ttttttcatt     240
 attttcattg aaaattagtg tcaaaatatg tataaatcaa tatttatctg aaaataactg     300
 gaaatataga gaaagtgctc caaaatggcc aaaacgttgt caattgccga agacgatact     360
 ctataataaa cggcaattgg caactttcgg gctgtttttc aacactgttc aatttgtcag     420
 atgaaaataa ttttattttc agttaactca agtgattttc tatattgtgg cagtgaaaaa     480
 aattcatagg ccattttgta gaattgccga aaataactcc acctctgaat tacatgcatt     540
 ttcactagaa aatatcattt acatacattt taatttataa atatccagta tttatttatt     600
 ttcttaaact cattttcaag aaaaatattt tcagctaatc gagaaaacga gaatggccta     660
 attgttcgaa tcgacaaaca ggaagacttc aaaaatctcg attcttgctg gaattcattt     720
 tatcccaaat attccgggaa atattgggca cttctcccag tcaatttgat tcgtcgtgat     780
 acaatttctc aattgaaatc atcgaaatgt ctttctggaa tagtattata taatagtgga     840
 gaatctattc atccaggaga tgaatcaaca gcagcttcac atgatgcaga atgtccaaat     900
 gctgcaagtg attattatct tcaagataaa aatgaagaat attgtgaaag aaagattaat     960
 tctcggggtg ctataacacg agatggatta atgaaaattg attggcggat acaaatggta    1020
 tttattgata attcaactga tttggaaatc attgagaaat gttattcaat gttcaataaa    1080
 ccaaaagaag atggttcatc tggatatcca tattgtggaa tgagctttcg tttggctaat    1140
 atggcggctg gaaattcaga aatttgctat cggcgtggaa aaaacgatgc aaagctgttt    1200
 cagatgaata ttgatagcgg gtaggttttt aaattttaag cagttaaaag aggtgaattt    1260
 ttgcattatt aaatgcagaa tagaccgtaa atattgcatg atgagatgta tttcatgata    1320
 atattcttta agaaaataaa tttgaaaatt tcataggaaa ataaacaaaa ttttgctaaa    1380
 cttcatagtt tggcatttct tatctcgttt tttgttaatt taggggattt tttagtcaat    1440
 aattgcaccg attccatgta tctctttttt tcgaatgata ttgtacctat atgccagacg    1500
 agctataatt tcctaatttt aaaaaataaa ttgtccaact caatgcctca atagttgaag    1560
 ttttccagag atgctcctca actctgtggt gcaatgcaca gtgacaatat atttgcattt    1620
 ccaactccaa ttccaacttc tccaacaaat gagacaataa tcacgagcaa atatatgatg    1680
 gtaactgctc gaatggacag ttttggaatg attccagaga tttctgttgg cgaagtatcc    1740
 gtactaactt caattatttc tgtactcgca gcagctcgat caatgggaac acagatcgaa    1800
 aaatggcaga aagcatcgaa tacttcgaat cgtaatgttt tctttgcttt tttcaatggt    1860
 gaatcgttgg attatattgg aagtggtgcg gctgcgtatc agatggagta agttggaaaa    1920
 tttaatttaa aaaacgttct agaactagta actgatcaaa aaaatttccc tattaacata    1980
 aaatggccca aaaattccta aaaatttcaa aatttcaaaa aaaaaaatag ttcgggcaaa    2040
 aaacataatt ctagctgaaa cctcaaattt ggcaagcttt tcaggctcgt aacatatttt    2100
 tggaagtcgt caatcaaaaa ataattcagt tttattcatt tatgataatt aattaaaatt    2160
 ttccaacatt gtttgaaaat ttttataatg atatttggtc attttaccat aattggaatg    2220
 gttttcaatt attttcccac tcttccttta gagaaaaaat atatttgtct tcagaaatgg    2280
 aaagttccca caaatgattc gctctgatcg aacacacatt catccaattc gcccgaatga    2340
 gttagattat atactggaag tacaacaaat tggagttgct aaaggacgaa aatattatgt    2400
 acacgttgat ggagaacgat atcaacagaa taagacacag acagatcgag ttattgatcg    2460
 aattgaacga ggtcttcgta gtcatgcttt tgatcttgaa aaaccatctg gaagtggaga    2520
 taggtgggtg catcgaaaat agtttttttt ttcaagaaca tacagaaaac gaaaagcttt    2580
 taaagcattt tctttaaaaa ttaaaacaat ttgagcatat gtaaactaca attccgagtg    2640
 tcgtttttcg aaaaaagtct aaaattaaaa aaaagcttat cgctcactat ttttcgaaaa    2700
 taaggtattt ttcctttaat aaaggcaaac gaaaaatctt cagccatgga taggtgaatt    2760
 atagaaataa ttttcaaaaa ttttcctttt tcagagttcc acccgcaagt tggcactcgt    2820
 ttgccaaggc tgatgctcac gttcaatcag ttctccttgc accatatggt aaagaatatg    2880
 aatatcaacg agttaattca attttggata aaaatgagtg gacagaagac gaacgagaga    2940
 aagcaattca agagattgaa gctgtttcta ctgctattct ggcagcagcc gctgattatg    3000
 ttggagttga aactgatgaa gttgttgcaa aagttgataa aaaattggta tgtattcttt    3060
 ttttttttaa ttttaaaact ttcagcgaca atttagatgt tttattgttg aatttgaaat    3120
 ttgcagtatt tttaaatact taaaacaaaa tccctgatga cgcagcgatt catcgctgta    3180
 ttttctaatt gctgaaattg aattccatat atatggaata tttcatatct ttacatataa    3240
 acgttttttt ttttcagata accactatat tcgattgtct catcacttcc aatttctggt    3300
 tcgactgtga ttttatgcaa aaactcgatg gcggtcgcta ccacaagctg tttaattcct    3360
 acggttttaa tcaaaaatca acatatattt caatggaatc ccatactgca ttccctaccg    3420
 tactccattg gttaactatt ttcgctttgg gtagtgacaa agaaacattg aatgtgaaaa    3480
 gtgaaaagag ctgctcacat cttggtcaat ttcaagcggt gagtttttat tttaaacgaa    3540
 tatcaaataa ttaaaatagt tttccgccag tttcagatgt atacctacac gtggcaaccg    3600
 aatccgtaca ccggaaattt cagttgtctg aaatctgcaa ttgttaaaaa agtaatggtt    3660
 tcgccggctg tagattctca aacacccgaa gaagaaatga acacgagata ttcaacatgg    3720
 atggaatcag tttatattat tgaatctgtg aatttatatt tgatggaaga tgcttcattt    3780
 gaatatacaa tgattctgat tgcggttatt tctgctttat tatcaatctt tgcagttggt    3840
 tagttttttt ttcaaaaaaa aaattacaaa aataaatcac aagctttcga gctttctcgt    3900
 attcgaaaat gaaggagttt cgcattaaag aaaactagat tttgaatcag tttttctaat    3960
 ctttagagaa attatactca catttgatgc ccagaaaagt ttgcgacttt tgagccaaaa    4020
 gcacggtgcc aggtctcgac acgaaaaatt tatattaatt gaaaatatgt ttgcgccttt    4080
 aaatggtact gtattttcga attctcattg ctggcgattt aaaaaaatgc attttttaaa    4140
 tccataaaag ttgagaaaaa tcgatgaaaa attgcacaga aatgagtgca agaaattaca    4200
 gtattcttta aaggcgcaca ccttttcgca tttcacaaaa tttcatcgtg tcgataccgg    4260
 gtaccgtatt ttggaggcaa aaatcgcaaa atctcgcgtc tggataatat cgtttatcgt    4320
 ttattgaagg aagtttttaa aaataagaaa aattgacagc tgcgagaaat tatgcataat    4380
 ttataaaaca ataaaaattt tttttttcag gtcgctgttc tgaaacaaca tttatcgttg    4440
 acgagggaga accagcagcg gaaggaggag aacctcttta acaaattatt ctcttcaaca    4500
 atgtatcata aattgattaa tttatttaat atttatattc gaaaaaatgt tcccattttt    4560

       <210> 12
       <211> 721
       <212> PRT
       <213> C. Elegans

       <400> 12
 Met Lys Lys Trp Leu Val Ile Val Leu Ile Ile Ala Gly Ile Arg Cys
  1               5                  10                  15
 Asp Gly Phe Ser Asp Gln Val Phe Arg Thr Leu Phe Ile Gly Glu Gly
             20                  25                  30
 Asn Ala Cys Tyr Arg Thr Phe Asn Lys Thr His Glu Phe Gly Cys Gln
         35                  40                  45
 Ala Asn Arg Glu Asn Glu Asn Gly Leu Ile Val Arg Ile Asp Lys Gln
     50                  55                  60
 Glu Asp Phe Lys Asn Leu Asp Ser Cys Trp Asn Ser Phe Tyr Pro Lys
 65                  70                  75                  80
 Tyr Ser Gly Lys Tyr Trp Ala Leu Leu Pro Val Asn Leu Ile Arg Arg
                 85                  90                  95
 Asp Thr Ile Ser Gln Leu Lys Ser Ser Lys Cys Leu Ser Gly Ile Val
             100                 105                 110
 Leu Tyr Asn Ser Gly Glu Ser Ile His Pro Gly Asp Glu Ser Thr Ala
         115                 120                 125
 Ala Ser His Asp Ala Glu Cys Pro Asn Ala Ala Ser Asp Tyr Tyr Leu
     130                 135                 140
 Gln Asp Lys Asn Glu Glu Tyr Cys Glu Arg Lys Ile Asn Ser Arg Gly
 145                 150                 155                 160
 Ala Ile Thr Arg Asp Gly Leu Met Lys Ile Asp Trp Arg Ile Gln Met
                 165                 170                 175
 Val Phe Ile Asp Asn Ser Thr Asp Leu Glu Ile Ile Glu Lys Cys Tyr
             180                 185                 190
 Ser Met Phe Asn Lys Pro Lys Glu Asp Gly Ser Ser Gly Tyr Pro Tyr
         195                 200                 205
 Cys Gly Met Ser Phe Arg Leu Ala Asn Met Ala Ala Gly Asn Ser Glu
     210                 215                 220
 Ile Cys Tyr Arg Arg Gly Lys Asn Asp Ala Lys Leu Phe Gln Met Asn
 225                 230                 235                 240
 Ile Asp Ser Gly Asp Ala Pro Gln Leu Cys Gly Ala Met His Ser Asp
                 245                 250                 255
 Asn Ile Phe Ala Phe Pro Thr Pro Ile Pro Thr Ser Pro Thr Asn Glu
             260                 265                 270
 Thr Ile Ile Thr Ser Lys Tyr Met Met Val Thr Ala Arg Met Asp Ser
         275                 280                 285
 Phe Gly Met Ile Pro Glu Ile Ser Val Gly Glu Val Ser Val Leu Thr
     290                 295                 300
 Ser Ile Ile Ser Val Leu Ala Ala Ala Arg Ser Met Gly Thr Gln Ile
 305                 310                 315                 320
 Glu Lys Trp Gln Lys Ala Ser Asn Thr Ser Asn Arg Asn Val Phe Phe
                 325                 330                 335
 Ala Phe Phe Asn Gly Glu Ser Leu Asp Tyr Ile Gly Ser Gly Ala Ala
             340                 345                 350
 Ala Tyr Gln Met Glu Asn Gly Lys Phe Pro Gln Met Ile Arg Ser Asp
         355                 360                 365
 Arg Thr His Ile His Pro Ile Arg Pro Asn Glu Leu Asp Tyr Ile Leu
     370                 375                 380
 Glu Val Gln Gln Ile Gly Val Ala Lys Gly Arg Lys Tyr Tyr Val His
 385                 390                 395                 400
 Val Asp Gly Glu Arg Tyr Gln Gln Asn Lys Thr Gln Thr Asp Arg Val
                 405                 410                 415
 Ile Asp Arg Ile Glu Arg Gly Leu Arg Ser His Ala Phe Asp Leu Glu
             420                 425                 430
 Lys Pro Ser Gly Ser Gly Asp Arg Val Pro Pro Ala Ser Trp His Ser
         435                 440                 445
 Phe Ala Lys Ala Asp Ala His Val Gln Ser Val Leu Leu Ala Pro Tyr
     450                 455                 460
 Gly Lys Glu Tyr Glu Tyr Gln Arg Val Asn Ser Ile Leu Asp Lys Asn
 465                 470                 475                 480
 Glu Trp Thr Glu Asp Glu Arg Glu Lys Ala Ile Gln Glu Ile Glu Ala
                 485                 490                 495
 Val Ser Thr Ala Ile Leu Ala Ala Ala Ala Asp Tyr Val Gly Val Glu
             500                 505                 510
 Thr Asp Glu Val Val Ala Lys Val Asp Lys Lys Leu Ile Thr Thr Ile
         515                 520                 525
 Phe Asp Cys Leu Ile Thr Ser Asn Phe Trp Phe Asp Cys Asp Phe Met
     530                 535                 540
 Gln Lys Leu Asp Gly Gly Arg Tyr His Lys Leu Phe Asn Ser Tyr Gly
 545                 550                 555                 560
 Phe Asn Gln Lys Ser Thr Tyr Ile Ser Met Glu Ser His Thr Ala Phe
                 565                 570                 575
 Pro Thr Val Leu His Trp Leu Thr Ile Phe Ala Leu Gly Ser Asp Lys
             580                 585                 590
 Glu Thr Leu Asn Val Lys Ser Glu Lys Ser Cys Ser His Leu Gly Gln
         595                 600                 605
 Phe Gln Ala Met Tyr Thr Tyr Thr Trp Gln Pro Asn Pro Tyr Thr Gly
     610                 615                 620
 Asn Phe Ser Cys Leu Lys Ser Ala Ile Val Lys Lys Val Met Val Ser
 625                 630                 635                 640
 Pro Ala Val Asp Ser Gln Thr Pro Glu Glu Glu Met Asn Thr Arg Tyr
                 645                 650                 655
 Ser Thr Trp Met Glu Ser Val Tyr Ile Ile Glu Ser Val Asn Leu Tyr
             660                 665                 670
 Leu Met Glu Asp Ala Ser Phe Glu Tyr Thr Met Ile Leu Ile Ala Val
         675                 680                 685
 Ile Ser Ala Leu Leu Ser Ile Phe Ala Val Gly Arg Cys Ser Glu Thr
     690                 695                 700
 Thr Phe Ile Val Asp Glu Gly Glu Pro Ala Ala Glu Gly Gly Glu Pro
 705                 710                 715                 720
 Leu
 

       <210> 13
       <211> 2949
       <212> DNA
       <213> human

       <400> 13
 tctgcagaat tcggcttgcg cctggaaaca cgaacttccg gtctcttagg ctccgggcca      60
 cagagacggt gtcagtggta gcctagagag gccgctaaca gacaggagcc gaacgggggc     120
 ttccgctcag cagagaggca agatggctac ggcagggggt ggctctgggg ctgacccggg     180
 aagtcggggt ctccttcgcc ttctgtcttt ctgcgtccta ctagcaggtt tgtgcagggg     240
 aaactcagtg gagaggaaga tatatatccc cttaaataaa acagctccct gtgttcgcct     300
 gctcaacgcc actcatcaga ttggctgcca gtcttcaatt agtggagaca caggggttat     360
 ccacgtagta gagaaagagg aggacctaca gtgggtattg actgatggcc ccaacccccc     420
 ttacatggtt ctgctggaga gcaagcattt taccagggat ttaatggaga agctgaaagg     480
 gagaaccagc cgaattgctg gtcttgcagt gtccttgacc aagcccagtc ctgcctcagg     540
 cttctctcct agtgtacagt gcccaaatga tgggtttggt gtttactcca attcctatgg     600
 gccagagttt gctcactgca gagaaataca gtggaattcg ctgggcaatg gtttggctta     660
 tgaagacttt agtttcccca tctttcttct tgaagatgaa aatgaaacca aagtcatcaa     720
 gcagtgctat caagatcaca acctgagtca gaatggctca gcaccaacct tcccactatg     780
 tgccatgcag ctcttttcac acatgcatgc tgtcatcagc actgccacct gcatgcggcg     840
 cagctccatc caaagcacct tcagcatcaa cccagaaatc gtctgtgacc ccctgtctga     900
 ttacaatgtg tggagcatgc taaagcctat aaatacaact gggacattaa agcctgacga     960
 cagggttgtg gttgctgcca cccggctgga tagtcgttcc tttttctgga atgtggcccc    1020
 aggggctgaa agcgcagtgg cttcctttgt cacccagctg gctgctgctg aagctttgca    1080
 aaaggcacct gatgtgacca ccctgccccg caatgtcatg tttgtcttct ttcaagggga    1140
 aacttttgac tacattggca gctcgaggat ggtctacgat atggagaagg gcaagtttcc    1200
 cgtgcagtta gagaatgttg actcatttgt ggagctggga caggtggcct taagaacttc    1260
 attagagctt tggatgcaca cagatcctgt ttctcagaaa aatgagtctg tacggaacca    1320
 ggtggaggat ctcctggcca cattggagaa gagtggtgct ggtgtccctg ctgtcatcct    1380
 caggaggcca aatcagtccc agcctctccc accatcttcc ctgcagcgat ttcttcgagc    1440
 tcgaaacatc tctggcgttg ttctggctga ccactctggt gccttccata acaaatatta    1500
 ccagagtatt tacgacactg ctgagaacat taatgtgagc tatcccgaat ggctgagccc    1560
 tgaagaggac ctgaactttg taacagacac tgccaaggcc ctggcagatg tggccacggt    1620
 gctgggacgt gctctgtatg agcttgcagg aggaaccaac ttcagcgaca cagttcaggc    1680
 tgatccccaa acggttaccc gcctgctcta tgggttcctg attaaagcca acaactcatg    1740
 gttccagtct atcctcaggc aggacctaag gtcctacttg ggtgacgggc ctcttcaaca    1800
 ttacatcgct gtctccagcc ccaccaacac cacttatgtt gtacagtatg ccttggcaaa    1860
 tttgactggc acagtggtca acctcacccg agagcagtgc caggatccaa gtaaagtccc    1920
 aagtgaaaac aaggatctgt atgagtactc atgggtccag ggccctttgc attctaatga    1980
 gacggaccga ctcccccggt gtgtgcgttc tactgcacga ttagccaggg ccttgtctcc    2040
 tgcctttgaa ctgagtcagt ggagctctac tgaatactct acatggactg agagccgctg    2100
 gaaagatatc cgtgcccgga tatttctcat cgccagcaaa gagcttgagt tgatcaccct    2160
 gacagtgggc ttcggcatcc tcatcttctc cctcatcgtc acctactgca tcaatgccaa    2220
 agctgatgtc cttttcattg ctccccggga gccaggagct gtgtcatact gagsaggacc    2280
 scagcttttc ttgccagctc agcagttcac ttcctagagc atctgtccca ctgggacaca    2340
 accactaatt tgtcactgga acctccctgg gcctgtctca gattgggatt aacataaaag    2400
 agtggaacta tccaaaagag acagggagaa ataaataaat tgcctccctt cctccgctcc    2460
 cctttcccat caccccttcc ccatttcctc ttccttctct actcatgcca gattttggga    2520
 ttacaaatag aagcttcttg ctcctgttta actccctagt tacccaccct aatttgccct    2580
 tcaggaccct tctacttttt ccttcctgcc ctgtacctct ctctgctcct cacccccacc    2640
 cctgtaccca gccaccttcc tgactgggaa ggacataaaa ggtttaatgt cagggtcaaa    2700
 ctacattgag cccctgagga caggggcatc tctgggctga gcctactgtc tccttcccac    2760
 tgtcctttct ccaggccctc agatggcaca ttagggtggg cgtgctgcgg gtgggtatcc    2820
 cacctccagc ccacagtgct cagttgtact ttttattaag ctgtaatatc tatttttgtt    2880
 tttgtctttt tcctttattc tttttgtaaa tatatatata atgagtttca ttaaaataga    2940
 ttatcccac                                                            2949

       <210> 14
       <211> 709
       <212> PRT
       <213> human

       <400> 14
 Met Ala Thr Ala Gly Gly Gly Ser Gly Ala Asp Pro Gly Ser Arg Gly
  1               5                  10                  15
 Leu Leu Arg Leu Leu Ser Phe Cys Val Leu Leu Ala Gly Leu Cys Arg
             20                  25                  30
 Gly Asn Ser Val Glu Arg Lys Ile Tyr Ile Pro Leu Asn Lys Thr Ala
         35                  40                  45
 Pro Cys Val Arg Leu Leu Asn Ala Thr His Gln Ile Gly Cys Gln Ser
     50                  55                  60
 Ser Ile Ser Gly Asp Thr Gly Val Ile His Val Val Glu Lys Glu Glu
 65                  70                  75                  80
 Asp Leu Gln Trp Val Leu Thr Asp Gly Pro Asn Pro Pro Tyr Met Val
                 85                  90                  95
 Leu Leu Glu Ser Lys His Phe Thr Arg Asp Leu Met Glu Lys Leu Lys
             100                 105                 110
 Gly Arg Thr Ser Arg Ile Ala Gly Leu Ala Val Ser Leu Thr Lys Pro
         115                 120                 125
 Ser Pro Ala Ser Gly Phe Ser Pro Ser Val Gln Cys Pro Asn Asp Gly
     130                 135                 140
 Phe Gly Val Tyr Ser Asn Ser Tyr Gly Pro Glu Phe Ala His Cys Arg
 145                 150                 155                 160
 Glu Ile Gln Trp Asn Ser Leu Gly Asn Gly Leu Ala Tyr Glu Asp Phe
                 165                 170                 175
 Ser Phe Pro Ile Phe Leu Leu Glu Asp Glu Asn Glu Thr Lys Val Ile
             180                 185                 190
 Lys Gln Cys Tyr Gln Asp His Asn Leu Ser Gln Asn Gly Ser Ala Pro
         195                 200                 205
 Thr Phe Pro Leu Cys Ala Met Gln Leu Phe Ser His Met His Ala Val
     210                 215                 220
 Ile Ser Thr Ala Thr Cys Met Arg Arg Ser Ser Ile Gln Ser Thr Phe
 225                 230                 235                 240
 Ser Ile Asn Pro Glu Ile Val Cys Asp Pro Leu Ser Asp Tyr Asn Val
                 245                 250                 255
 Trp Ser Met Leu Lys Pro Ile Asn Thr Thr Gly Thr Leu Lys Pro Asp
             260                 265                 270
 Asp Arg Val Val Val Ala Ala Thr Arg Leu Asp Ser Arg Ser Phe Phe
         275                 280                 285
 Trp Asn Val Ala Pro Gly Ala Glu Ser Ala Val Ala Ser Phe Val Thr
     290                 295                 300
 Gln Leu Ala Ala Ala Glu Ala Leu Gln Lys Ala Pro Asp Val Thr Thr
 305                 310                 315                 320
 Leu Pro Arg Asn Val Met Phe Val Phe Phe Gln Gly Glu Thr Phe Asp
                 325                 330                 335
 Tyr Ile Gly Ser Ser Arg Met Val Tyr Asp Met Glu Lys Gly Lys Phe
             340                 345                 350
 Pro Val Gln Leu Glu Asn Val Asp Ser Phe Val Glu Leu Gly Gln Val
         355                 360                 365
 Ala Leu Arg Thr Ser Leu Glu Leu Trp Met His Thr Asp Pro Val Ser
     370                 375                 380
 Gln Lys Asn Glu Ser Val Arg Asn Gln Val Glu Asp Leu Leu Ala Thr
 385                 390                 395                 400
 Leu Glu Lys Ser Gly Ala Gly Val Pro Ala Val Ile Leu Arg Arg Pro
                 405                 410                 415
 Asn Gln Ser Gln Pro Leu Pro Pro Ser Ser Leu Gln Arg Phe Leu Arg
             420                 425                 430
 Ala Arg Asn Ile Ser Gly Val Val Leu Ala Asp His Ser Gly Ala Phe
         435                 440                 445
 His Asn Lys Tyr Tyr Gln Ser Ile Tyr Asp Thr Ala Glu Asn Ile Asn
     450                 455                 460
 Val Ser Tyr Pro Glu Trp Leu Ser Pro Glu Glu Asp Leu Asn Phe Val
 465                 470                 475                 480
 Thr Asp Thr Ala Lys Ala Leu Ala Asp Val Ala Thr Val Leu Gly Arg
                 485                 490                 495
 Ala Leu Tyr Glu Leu Ala Gly Gly Thr Asn Phe Ser Asp Thr Val Gln
             500                 505                 510
 Ala Asp Pro Gln Thr Val Thr Arg Leu Leu Tyr Gly Phe Leu Ile Lys
         515                 520                 525
 Ala Asn Asn Ser Trp Phe Gln Ser Ile Leu Arg Gln Asp Leu Arg Ser
     530                 535                 540
 Tyr Leu Gly Asp Gly Pro Leu Gln His Tyr Ile Ala Val Ser Ser Pro
 545                 550                 555                 560
 Thr Asn Thr Thr Tyr Val Val Gln Tyr Ala Leu Ala Asn Leu Thr Gly
                 565                 570                 575
 Thr Val Val Asn Leu Thr Arg Glu Gln Cys Gln Asp Pro Ser Lys Val
             580                 585                 590
 Pro Ser Glu Asn Lys Asp Leu Tyr Glu Tyr Ser Trp Val Gln Gly Pro
         595                 600                 605
 Leu His Ser Asn Glu Thr Asp Arg Leu Pro Arg Cys Val Arg Ser Thr
     610                 615                 620
 Ala Arg Leu Ala Arg Ala Leu Ser Pro Ala Phe Glu Leu Ser Gln Trp
 625                 630                 635                 640
 Ser Ser Thr Glu Tyr Ser Thr Trp Thr Glu Ser Arg Trp Lys Asp Ile
                 645                 650                 655
 Arg Ala Arg Ile Phe Leu Ile Ala Ser Lys Glu Leu Glu Leu Ile Thr
             660                 665                 670
 Leu Thr Val Gly Phe Gly Ile Leu Ile Phe Ser Leu Ile Val Thr Tyr
         675                 680                 685
 Cys Ile Asn Ala Lys Ala Asp Val Leu Phe Ile Ala Pro Arg Glu Pro
     690                 695                 700
 Gly Ala Val Ser Tyr
 705

       <210> 15
       <211> 2250
       <212> DNA
       <213> mouse

       <400> 15
 cccagcggag aggcaacatg gctacgacta ggggcggctc tgggcctgac ccaggaagtc      60
 ggggtcttct tcttctgtct ttttccgtgg tactggcagg attgtgtggg ggaaactcag     120
 tggagaggaa aatctacatt cccttaaata aaacagctcc ttgtgtccgc ctgctcaacg     180
 ccactcatca gattggctgc cagtcttcaa ttagtgggga tacaggggtt atccacgtag     240
 tggagaaaga agaagacctg aagtgggtgt tgaccgatgg ccccaacccc ccttacatgg     300
 ttctgctgga gggcaagctc ttcaccagag atgtaatgga gaagctgaag ggaacaacca     360
 gtagaatcgc tggtcttgcc gtgactctag ccaagcccaa ctcaacttca agcttctctc     420
 ctagtgtgca gtgcccaaat gatgggtttg gtatttactc caactcctac gggccagagt     480
 ttgctcactg caagaaaaca ctgtggaatg aactgggcaa cggcttggct tatgaagact     540
 ttagtttccc catctttctt cttgaagatg agaacgaaac caaggtcatc aagcagtgct     600
 atcaagatca caacctgggt cagaatggct ctgcaccaag cttcccattg tgtgctatgc     660
 agctcttctc acacatgcac gccgtcatca gcactgccac ctgcatgcgg cgcagcttca     720
 tccagagcac cttcagcatc aacccagaaa tcgtctgtga ccccttatct gactacaacg     780
 tatggagcat gcttaagcct ataaatacat ctgtgggact agaacctgac gtcagggttg     840
 tggttgcggc cacacggctg gatagccggt cctttttctg gaatgtggcc ccaggggctg     900
 aaagtgctgt agcctccttt gtcactcagc tggctgcagc tgaagctttg cacaaggcac     960
 ctgatgtgac cactctatcc cgaaatgtga tgtttgtctt cttccagggg gaaacttttg    1020
 actacattgg cagctcacgg atggtctatg atatggagaa cggcaagttt cccgtgcggc    1080
 tcgagaacat cgactccttc gtggagctgg gacaggtggc cctaagaact tcactagatc    1140
 tctggatgca cacagatccc atgtctcaga aaaatgagtc tgtgaaaaac caggtggagg    1200
 atcttctggc cactctggag aagagcggtg ctggtgtccc tgaagttgtc ctgaggagac    1260
 tggcccagtc ccaggccctt ccaccttcat ctctacaacg atttcttcgg gctcgaaaca    1320
 tctctggcgt ggtcctggct gaccactctg gctccttcca caatcggtat taccagagca    1380
 tttatgacac ggctgagaac attaatgtga cctatcctga gtggcagagc ccagaagagg    1440
 acctcaactt tgtgacagac actgccaagg cactggcgaa tgtggccaca gtgctggcgc    1500
 gtgcactgta tgagcttgca ggaggaacca acttcagcag ctccatccag gctgatcccc    1560
 agacagttac acgtctgctc tatgggttcc tggttagagc taacaactca tggtttcagt    1620
 cgatcctgaa acatgaccta aggtcctatt tggatgacag gcctcttcaa cactacatcg    1680
 ccgtctccag ccctaccaac acgacttacg ttgtgcagta cgccttggca aacctgactg    1740
 gcaaggcgac caacctcacc cgagagcagt gccaggatcc aagtaaagtc ccaaatgaga    1800
 gcaaggattt atatgaatac tcgtgggtac aaggcccttg gaattccaac aggacagaga    1860
 ggctcccaca gtgtgtgcgc tccacagtgc gactggccag ggccttgtcc cctgcctttg    1920
 aactgagtca gtggagctcc acagaatact ctacgtgggc ggagagccgc tggaaagaca    1980
 tccaagctcg gatattccta attgccagca aagagcttga gttcatcacg ctgatcgtgg    2040
 gcttcagcac ccttgtcttc tctctcatcg tcacctactg catcaatgcc aaagccgacg    2100
 tccttttygt tgctccccga gagccaggag ctgtgtctta ctgaagagga ctctagctct    2160
 ccctgcctgc tctgaacttt acttcccaga ccaggtgtcc ggctgggaac aaaccactaa    2220
 tttgtcactg gactgtctct gggcctgctt                                     2250

       <210> 16
       <211> 708
       <212> PRT
       <213> mouse

       <400> 16
 Met Ala Thr Thr Arg Gly Gly Ser Gly Pro Asp Pro Gly Ser Arg Gly
  1               5                  10                  15
 Leu Leu Leu Leu Ser Phe Ser Val Val Leu Ala Gly Leu Cys Gly Gly
             20                  25                  30
 Asn Ser Val Glu Arg Lys Ile Tyr Ile Pro Leu Asn Lys Thr Ala Pro
         35                  40                  45
 Cys Val Arg Leu Leu Asn Ala Thr His Gln Ile Gly Cys Gln Ser Ser
     50                  55                  60
 Ile Ser Gly Asp Thr Gly Val Ile His Val Val Glu Lys Glu Glu Asp
 65                  70                  75                  80
 Leu Lys Trp Val Leu Thr Asp Gly Pro Asn Pro Pro Tyr Met Val Leu
                 85                  90                  95
 Leu Glu Gly Lys Leu Phe Thr Arg Asp Val Met Glu Lys Leu Lys Gly
             100                 105                 110
 Thr Thr Ser Arg Ile Ala Gly Leu Ala Val Thr Leu Ala Lys Pro Asn
         115                 120                 125
 Ser Thr Ser Ser Phe Ser Pro Ser Val Gln Cys Pro Asn Asp Gly Phe
     130                 135                 140
 Gly Ile Tyr Ser Asn Ser Tyr Gly Pro Glu Phe Ala His Cys Lys Lys
 145                 150                 155                 160
 Thr Leu Trp Asn Glu Leu Gly Asn Gly Leu Ala Tyr Glu Asp Phe Ser
                 165                 170                 175
 Phe Pro Ile Phe Leu Leu Glu Asp Glu Asn Glu Thr Lys Val Ile Lys
             180                 185                 190
 Gln Cys Tyr Gln Asp His Asn Leu Gly Gln Asn Gly Ser Ala Pro Ser
         195                 200                 205
 Phe Pro Leu Cys Ala Met Gln Leu Phe Ser His Met His Ala Val Ile
     210                 215                 220
 Ser Thr Ala Thr Cys Met Arg Arg Ser Phe Ile Gln Ser Thr Phe Ser
 225                 230                 235                 240
 Ile Asn Pro Glu Ile Val Cys Asp Pro Leu Ser Asp Tyr Asn Val Trp
                 245                 250                 255
 Ser Met Leu Lys Pro Ile Asn Thr Ser Val Gly Leu Glu Pro Asp Val
             260                 265                 270
 Arg Val Val Val Ala Ala Thr Arg Leu Asp Ser Arg Ser Phe Phe Trp
         275                 280                 285
 Asn Val Ala Pro Gly Ala Glu Ser Ala Val Ala Ser Phe Val Thr Gln
     290                 295                 300
 Leu Ala Ala Ala Glu Ala Leu His Lys Ala Pro Asp Val Thr Thr Leu
 305                 310                 315                 320
 Ser Arg Asn Val Met Phe Val Phe Phe Gln Gly Glu Thr Phe Asp Tyr
                 325                 330                 335
 Ile Gly Ser Ser Arg Met Val Tyr Asp Met Glu Asn Gly Lys Phe Pro
             340                 345                 350
 Val Arg Leu Glu Asn Ile Asp Ser Phe Val Glu Leu Gly Gln Val Ala
         355                 360                 365
 Leu Arg Thr Ser Leu Asp Leu Trp Met His Thr Asp Pro Met Ser Gln
     370                 375                 380
 Lys Asn Glu Ser Val Lys Asn Gln Val Glu Asp Leu Leu Ala Thr Leu
 385                 390                 395                 400
 Glu Lys Ser Gly Ala Gly Val Pro Glu Val Val Leu Arg Arg Leu Ala
                 405                 410                 415
 Gln Ser Gln Ala Leu Pro Pro Ser Ser Leu Gln Arg Phe Leu Arg Ala
             420                 425                 430
 Arg Asn Ile Ser Gly Val Val Leu Ala Asp His Ser Gly Ser Phe His
         435                 440                 445
 Asn Arg Tyr Tyr Gln Ser Ile Tyr Asp Thr Ala Glu Asn Ile Asn Val
     450                 455                 460
 Thr Tyr Pro Glu Trp Gln Ser Pro Glu Glu Asp Leu Asn Phe Val Thr
 465                 470                 475                 480
 Asp Thr Ala Lys Ala Leu Ala Asn Val Ala Thr Val Leu Ala Arg Ala
                 485                 490                 495
 Leu Tyr Glu Leu Ala Gly Gly Thr Asn Phe Ser Ser Ser Ile Gln Ala
             500                 505                 510
 Asp Pro Gln Thr Val Thr Arg Leu Leu Tyr Gly Phe Leu Val Arg Ala
         515                 520                 525
 Asn Asn Ser Trp Phe Gln Ser Ile Leu Lys His Asp Leu Arg Ser Tyr
     530                 535                 540
 Leu Asp Asp Arg Pro Leu Gln His Tyr Ile Ala Val Ser Ser Pro Thr
 545                 550                 555                 560
 Asn Thr Thr Tyr Val Val Gln Tyr Ala Leu Ala Asn Leu Thr Gly Lys
                 565                 570                 575
 Ala Thr Asn Leu Thr Arg Glu Gln Cys Gln Asp Pro Ser Lys Val Pro
             580                 585                 590
 Asn Glu Ser Lys Asp Leu Tyr Glu Tyr Ser Trp Val Gln Gly Pro Trp
         595                 600                 605
 Asn Ser Asn Arg Thr Glu Arg Leu Pro Gln Cys Val Arg Ser Thr Val
     610                 615                 620
 Arg Leu Ala Arg Ala Leu Ser Pro Ala Phe Glu Leu Ser Gln Trp Ser
 625                 630                 635                 640
 Ser Thr Glu Tyr Ser Thr Trp Ala Glu Ser Arg Trp Lys Asp Ile Gln
                 645                 650                 655
 Ala Arg Ile Phe Leu Ile Ala Ser Lys Asp Leu Glu Phe Ile Thr Leu
             660                 665                 670
 Ile Val Gly Phe Ser Thr Leu Val Phe Ser Leu Ile Val Thr Tyr Cys
         675                 680                 685
 Ile Asn Ala Lys Ala Asp Val Leu Phe Val Ala Pro Arg Glu Pro Gly
     690                 695                 700
 Ala Val Ser Tyr
 705

       <210> 17
       <211> 2942
       <212> DNA
       <213> D. melanogaster

       <400> 17
 tctgatatca tcgccactgt gctgggaatt cggcacgagc gcaacactgc aatttctgga      60
 cgcgatttcg tgggaatctt cgatggaaat gcgtctgaat gcggcttcca tatggctgtt     120
 aatactgtcg tatggagcaa ctattgctca aggagaaaga acccgcgata agatgtacga     180
 gcccattgga ggagctagct gtttccgacg gctgaatggc acccatcaga caggctgttc     240
 ctcaacctac tccggttccg tgggcgtact acatctaata aacgtcgagg ccgacctgga     300
 atttcttctt agcagcccac catctccacc ttacgccccc atgataccac ctcacctgtt     360
 cacacgtaac aacctgatgc gcctaaagga agccggacca aagaacattt ctgtggtgct     420
 gctgatcaac cgcacgaacc agatgaagca gttctcgcac gaactcaact gccccaatca     480
 gtacagcggc ctgaacagca ccagtgagac ctgcgacgcc agcaatccag ccaaaaactg     540
 gaatccctgg ggcactggac ttctgcacga ggactttccc tttcctatct attacatagc     600
 cgatttggat caggtcacca agctagagaa gtgctttcag gactttaaca accataacta     660
 cgagacgcac gcgctgcgta gcttgtgcgc cgtcgaggtc aagtccttta tgtccgccgc     720
 tgtcaacacc gaggtctgta tgcgccgcac caacttcatc aataatcttg gaggaagcaa     780
 gtactgcgat ccgctcgagg gacggaatgt ttcgccacct tgtacccccg aaagccagca     840
 atcggaaaca actttggaga cagtccatac gaatgaaaag ttcatattag taacctgtcg     900
 cctggacacc accaccatgt tcgatggcgt cggtcttgga gccatggact ccctcatggg     960
 atttgctgtt ttcactcatg tggcgtatct attaaaacaa ctacttccgc cgcaaagcaa    1020
 agaccttcat aatgtcctct ttgtgacttt taatggcgaa tcctatgact acattggttc    1080
 tcaaagattt gtatacgaca tggagaaact tcaatttcct actgaatcca caggcacgcc    1140
 tccgattgcc tttgacaata ttgacttcat gctggacatc gggacactgg atgacatatc    1200
 gaatattaag ctgcatgcgt taaatggaac gactttggct cagcaaattc tagagcggct    1260
 aaataactat gcgaagtcgc cacgctatgg ctttaacctg aacattcagt ccgagatgag    1320
 cgctcactta ccacctacgt cggcgcaatc atttctgcga cgtgatccaa acttcaatgc    1380
 attgattcta aacgctcgtc caacgaacaa gtattatcat tccacatacg atgacgcgga    1440
 taacgtggac ttcacctatg cgaacacaag caaggatttc acccagctga cggaagttaa    1500
 tgactttaaa agcttgaacc cagattcact gcaaatgaaa gtgcgcaacg tttcctctat    1560
 tgtggccatg gccctatatc agacaataac tggaaaggag tacactggca ccaaggtggc    1620
 caaccctctg atggcagatg agttccttta ctgtttcctg caatcggcgg actgcccact    1680
 ctttaaggcc gcatcttatc cgggcagtca gctcaccaat ttgcctccga tgcgctacat    1740
 aagcgtcttg ggtggctctc aagagtcgtc gggctatacg tatagattgc tgggctatct    1800
 cttgtcacaa ctgcagccag acattcacag agataactgc accgacttgc cgctgcacta    1860
 tttcgccgga ttcaacaata tcggagagtg tcgcctcacc acgcagaact acagtcacgc    1920
 cctgagtcca gcttttctta ttgatggcta cgattggagt tccggcatgt attccacttg    1980
 gactgaatcc acctggtcac agttcagtgc acgcatcttc ctgcgcccgt ccaatgtgca    2040
 ccaggtcaca actctaagcg ttggcatagt ggtgctgata atatccttct gtttggtgta    2100
 tataatcagc tcacgatcgg aagtcctctt tgaggatttg ccggcaagca atgccgcatt    2160
 atttggttga tgtcacaact gccacagcga cgaaatcatc gcgttcagca gctcattcca    2220
 tagatttctg catgcgtaaa ctaaacgtta cttgtaaacc aatcgattaa gaatttctga    2280
 ttgtgccctt ttagatcgcc gcggccgaca gcctgttaaa tcttcaaaga atatctgatc    2340
 acgtgccgaa gatgattggt tgctgaatat gatctaaaac aaaaaacaga cttaacaaag    2400
 acactaaaat gatattctaa ctcgtcttat ttaaaacatt aagcaaacgt ttatttatat    2460
 gtatttttgt attttaaagt agtaaattag cttctatcaa ctacgttgta tcatatatag    2520
 acatttaacc aattgcgaca aaattctttc cacttgtccg gccctttttg cattgtacat    2580
 aggattaacc aacccaattg aacctctgat aatgccaagg aagagatgtc tgtacaaata    2640
 ttgacaagaa actgctataa cttataaatc actggaaata tttatacctt ctgcatctat    2700
 tgcgatactg aacttaatga tctgaaatca ttacttcata gaagacaaat aattattata    2760
 acgactttaa attatatatg tttaataaat tttgataagg tgtaaagcaa tgtcctgtta    2820
 tctagttagg ttattttcaa ggcaattatt cacagctctc agattccaac gattgatgta    2880
 gtttaatctc aactctttac caaagaagtc catttgtact agtgtaaaag atattttcaa    2940
 ta                                                                   2942

       <210> 18
       <211> 695
       <212> PRT
       <213> D. melanogaster

       <400> 18
 Met Glu Met Arg Leu Asn Ala Ala Ser Ile Trp Leu Leu Ile Leu Ser
  1               5                  10                  15
 Tyr Gly Ala Thr Ile Ala Gln Gly Glu Arg Thr Arg Asp Lys Met Tyr
             20                  25                  30
 Glu Pro Ile Gly Gly Ala Ser Cys Phe Arg Arg Leu Asn Gly Thr His
         35                  40                  45
 Gln Thr Gly Cys Ser Ser Thr Tyr Ser Gly Ser Val Gly Val Leu His
     50                  55                  60
 Leu Ile Asn Val Glu Ala Asp Leu Glu Phe Leu Leu Ser Ser Pro Pro
 65                  70                  75                  80
 Ser Pro Pro Tyr Ala Pro Met Ile Pro Pro His Leu Phe Thr Arg Asn
                 85                  90                  95
 Asn Leu Met Arg Leu Lys Glu Ala Gly Pro Lys Asn Ile Ser Val Val
             100                 105                 110
 Leu Leu Ile Asn Arg Thr Asn Gln Met Lys Gln Phe Ser His Glu Leu
         115                 120                 125
 Asn Cys Pro Asn Gln Tyr Ser Gly Leu Asn Ser Thr Ser Glu Thr Cys
     130                 135                 140
 Asp Ala Ser Asn Pro Ala Lys Asn Trp Asn Pro Trp Gly Thr Gly Leu
 145                 150                 155                 160
 Leu His Glu Asp Phe Pro Phe Pro Ile Tyr Tyr Ile Ala Asp Leu Asp
                 165                 170                 175
 Gln Val Thr Lys Leu Glu Lys Cys Phe Gln Asp Phe Asn Asn His Asn
             180                 185                 190
 Tyr Glu Thr His Ala Leu Arg Ser Leu Cys Ala Val Glu Val Lys Ser
         195                 200                 205
 Phe Met Ser Ala Ala Val Asn Thr Glu Val Cys Met Arg Arg Thr Asn
     210                 215                 220
 Phe Ile Asn Asn Leu Gly Gly Ser Lys Tyr Cys Asp Pro Leu Glu Gly
 225                 230                 235                 240
 Arg Asn Val Ser Pro Pro Cys Thr Pro Glu Ser Gln Gln Ser Glu Thr
                 245                 250                 255
 Thr Leu Glu Thr Val His Thr Asn Glu Lys Phe Ile Leu Val Thr Cys
             260                 265                 270
 Arg Leu Asp Thr Thr Thr Met Phe Asp Gly Val Gly Leu Gly Ala Met
         275                 280                 285
 Asp Ser Leu Met Gly Phe Ala Val Phe Thr His Val Ala Tyr Leu Leu
     290                 295                 300
 Lys Gln Leu Leu Pro Pro Gln Ser Lys Asp Leu His Asn Val Leu Phe
 305                 310                 315                 320
 Val Thr Phe Asn Gly Glu Ser Tyr Asp Tyr Ile Gly Ser Gln Arg Phe
                 325                 330                 335
 Val Tyr Asp Met Glu Lys Leu Gln Phe Pro Thr Glu Ser Thr Gly Thr
             340                 345                 350
 Pro Pro Ile Ala Phe Asp Asn Ile Asp Phe Met Leu Asp Ile Gly Thr
         355                 360                 365
 Leu Asp Asp Ile Ser Asn Ile Lys Leu His Ala Leu Asn Gly Thr Thr
     370                 375                 380
 Leu Ala Gln Gln Ile Leu Glu Arg Leu Asn Asn Tyr Ala Lys Ser Pro
 385                 390                 395                 400
 Arg Tyr Gly Phe Asn Leu Asn Ile Gln Ser Glu Met Ser Ala His Leu
                 405                 410                 415
 Pro Pro Thr Ser Ala Gln Ser Phe Leu Arg Arg Asp Pro Asn Phe Asn
             420                 425                 430
 Ala Leu Ile Leu Asn Ala Arg Pro Thr Asn Lys Tyr Tyr His Ser Thr
         435                 440                 445
 Tyr Asp Asp Ala Asp Asn Val Asp Phe Thr Tyr Ala Asn Thr Ser Lys
     450                 455                 460
 Asp Phe Thr Gln Leu Thr Glu Val Asn Asp Phe Lys Ser Leu Asn Pro
 465                 470                 475                 480
 Asp Ser Leu Gln Met Lys Val Arg Asn Val Ser Ser Ile Val Ala Met
                 485                 490                 495
 Ala Leu Tyr Gln Thr Ile Thr Gly Lys Glu Tyr Thr Gly Thr Lys Val
             500                 505                 510
 Ala Asn Pro Leu Met Ala Asp Glu Phe Leu Tyr Cys Phe Leu Gln Ser
         515                 520                 525
 Ala Asp Cys Pro Leu Phe Lys Ala Ala Ser Tyr Pro Gly Ser Gln Leu
     530                 535                 540
 Thr Asn Leu Pro Pro Met Arg Tyr Ile Ser Val Leu Gly Gly Ser Gln
 545                 550                 555                 560
 Glu Ser Ser Gly Tyr Thr Tyr Arg Leu Leu Gly Tyr Leu Leu Ser Gln
                 565                 570                 575
 Leu Gln Pro Asp Ile His Arg Asp Asn Cys Thr Asp Leu Pro Leu His
             580                 585                 590
 Tyr Phe Ala Gly Phe Asn Asn Ile Gly Glu Cys Arg Leu Thr Thr Gln
         595                 600                 605
 Asn Tyr Ser His Ala Leu Ser Pro Ala Phe Leu Ile Asp Gly Tyr Asp
     610                 615                 620
 Trp Ser Ser Gly Met Tyr Ser Thr Trp Thr Glu Ser Thr Trp Ser Gln
 625                 630                 635                 640
 Phe Ser Ala Arg Ile Phe Leu Arg Pro Ser Asn Val His Gln Val Thr
                 645                 650                 655
 Thr Leu Ser Val Gly Ile Val Val Leu Ile Ile Ser Phe Cys Leu Val
             660                 665                 670
 Tyr Ile Ile Ser Ser Arg Ser Glu Val Leu Phe Glu Asp Leu Pro Ala
         675                 680                 685
 Ser Asn Ala Ala Leu Phe Gly
     690                 695

       <210> 19
       <211> 17
       <212> PRT
       <213> human

       <400> 19
 Ala Arg Leu Ala Arg Ala Leu Ser Pro Ala Phe Glu Leu Ser Gln Trp
  1               5                  10                  15
 Ser

13

2

